Isolator systems

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Innovative synthetic resin isolators

What makes our cell culture and filling isolators so innovative is that we use a highly resistant acrylic resin – polymethyl methacrylate or PMMA – to create isolators tailored to your needs and available space. Common isolators are made of stainless steel, which corrodes over time due to H2Odecontamination cycles.

Integrity guaranteed

Thanks to the use of PMMA, our isolators maintain their integrity. The isolators are designed to allow you to operate in cleanliness conditions of grades D to A (ISO 8 to ISO 5) of cGMP requirements, meaning they are perfectly suited to ATMP and aseptic manufacturing.

Why our isolators are perfect for your operations


salamanderU’s cell culture and filling isolators are tailored to your aseptic operations. Whatever your needs or available space, we will make an isolator that works perfectly for you.

Efficient disinfection

Our isolators are easy to clean and disinfect. The working section, material airlock (MAL IN) and security airlock system (SAS) are each provided with an independent decontamination unit with vaporized hydrogen peroxide (H2O2). These separate systems enable some sections to be run through a decontamination cycle, while you continue using other sections.

Easy to control

With their human-machine interface (HMI) touch screens, salamanderU’s isolators are simple to control. The touch screen manages the decontamination cycle in each section and verifies the status of the sections being decontaminated. It also shows in real time whether the doors are opened or closed, the state of the filters, if the valves of the decontamination system and heating, ventilation, and air conditioning (HVAC) system are opened or closed, and if the HVAC has a correct flow rate.

Clear supervision

The HMI touch screen can display several critical parameters, such as temperature, pressure and relative humidity, which affect the isolator’s functioning. The parameters are shown for each section of the isolator and for the connected incubators.

Features of your choice

You decide on the features. As an example, here is what one of our customers wanted in their isolator with four main sections:

  • A MAL IN, a material airlock that allows materials to enter, such as reagents, raw materials and small pieces of equipment which help to complete the aseptic operations within the isolator. A watertight door to connect the MAL IN to the isolator’s bench.
  • A working section for all aseptic operations, connected on both sides to a SAS, safety airlock system, accessible through a watertight door. The working section also includes a DPTE Transfer Port System to allow sterile equipment to enter the isolator and waste and samples to exit.
  • One SAS equipped with a microscope and a centrifuge to transfer samples to a connected incubator.
  • A second SAS, also with a microscope, to transfer samples to a second incubator.

Our team also developed a full case study comparing process costs between our customized isolator and a regular aseptic area for another customer.

The final results overwhelmingly favor our customized isolator:

  • More accurately defined manufacturing process
  • Improved aseptic operations
  • Automated bio-decontamination
  • OPEX decrease by 36%, with a Return on Investment of less than 3 years
  • FTE reduction

Contact us to get a copy of the study presentation we made and to talk to one of our experts